منابع مشابه
What makes placebo-controlled trials unethical?
The leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo. Invoking the principle of clinical equipoise, opponents of placebo-controlled trials in the face of proven effective treatment argue that they (1) violate the therapeutic obligatio...
متن کاملUnethical placebo assignment in clinical trials of thrombolysis.
Marcia Angell, Executive Editor of the New England Journal of Medicine, recently argued that "the most frequent types of unethical research occurring today involve obtaining informed consent as a legalism, without truly informing the subjects, and inappropriately using a placebo group in a clinical trial" (1). From Figure 1, showing the chronologic relation of the main placebo-controlled trials...
متن کاملUnregistered Trials Are Unethical
Susanne McCabe I fi nd the arguments raised by the PLoS Medicine editors very useful [1] as I had not considered that a scientifi c community would tolerate barring access to registers of trials. It leaves huge gaps for exploitation by privileged groups. It is not only colleagues in research and allied professions who need access but the global community, including members of the public whereve...
متن کاملUnethical Conduct of Underpowered Clinical Trials
I read with interest the article on the effect of antiseptics on the colonization rate of central venous catheters, published in the recent issue of your Journal.1 Although the topic is very important, the study suffers from many shortcomings, the most important of which is low study power. Assuming expected prevalence rates of 22% and 17% in the control and treatment groups (an effect size of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2000
ISSN: 1078-8956,1546-170X
DOI: 10.1038/81268